Other drug interactions with grapefruit juice (or other juices) may occur. Estrogen, oral contraceptives ( birth control pills).Allegra® (fexofenadine): over-the-counter (OTC) allergy medicine.Pacerone ® (amiodarone): used to treat abnormal heart rhythm.Entocort ® EC and Uceris ® (both contain budesonide).Statins (used to treat high cholesterol):Ĭalcium channel blockers (used to treat high blood pressure) The following drugs can interact with grapefruit juice: Keep in mind that the extent of the interaction varies by person, medicine, and the amount of grapefruit juice you drink. What Medications Interact with Grapefruit Juice? If too much atorvastatin or another statin builds up in your body, you can suffer from liver and muscle damage and even kidney failure.īecause everyone has a different amount of CYP3A4 in their intestines, grapefruit juice may affect people differently. When the enzyme can’t process the medication as efficiently, the drug levels can build up, causing worsened or more severe side effects. Many drugs are processed by an enzyme called cytochrome P450 3A4 (CYP3A4). How Does Grapefruit Juice Interact with Medications? Continue reading to learn all about grapefruit juice and drugs. Grapefruit juice interacts with certain medications, which can lead to unwanted consequences. The reason to avoid grapefruit is not that it is unhealthy. You may be thinking, what? Grapefruit juice? How does that affect my cholesterol? Isn’t grapefruit a healthy citrus fruit – full of vitamin C – that should be part of a balanced diet? Did he or she tell you also to avoid grapefruit and grapefruit juice? If you take cholesterol medication, like atorvastatin (Lipitor ®), your doctor probably told you to avoid fried foods, fatty foods, and sugar.
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